How Is BCL6 Related to Endometriosis?

What Is BCL6?

BCL-6 is a gene that encodes a tissue-building protein. Known for its role as a lymphoma marker, it has been found to be very useful in detecting uterine lining inflammation highly associated with endometriosis.

What is Endometriosis?

Endometriosis is a complex disease in which tissue that is similar to the endometrial lining of the uterus grows outside of the uterus. It typically grows on the ovaries, ovarian tubes, the outer wall of the uterus, the intestines, other organs in the abdomen and in some cases outside the abdomen. Pelvic pain and infertility are two of the hallmark symptoms of Endometriosis. Every month, the endometrial lining in the uterus thickens, sheds, and bleeds out during menstruation. The tissues retain such characteristics even when they grow in the fallopian tube. All endometrial tissues will thicken and shed during the menstrual cycle, but those in abnormal places won’t find a natural pathway to leave the body. The trapped tissues can cause irritation, cysts, scarring, and adhesions in the surrounding areas.

The Link Between BCL-6 and Endometriosis

Evidence relating to BCL6 endometriosis has been published for more than a decade. Since BCL66 was first offered as a test in 2017, more than 35,000 tests and over 25 studies have shown the relationship between positive BCL6 and endometriosis,

BCL6 Endometriosis Testing & Treatment

If you are experiencing any of the following symptoms ,the MyReceptiva test can be your first line of testing before undergoing expensive treatment or surgery.

Undiagnosed pelvic or abdominal pain.
Family history of endometriosis, pelvic or abdominal pain.
Pain during and after sex.
Getting up multiple times a night to urinate
Recurrent bladder or bowel pain.
High Body Mass Index (BMI) combined with non-specific symptoms such as anxiety, depression or fatigue.
Women 34 and under who have failed to conceive after 12 months of trying to conceive naturally.
Women 35 and over with unexplained infertility after 6 months of trying to conceive naturally.
Women with one or more consecutive miscarriages during the first 13 weeks of pregnancy.
Women and families want to screen before considering expensive next steps such as IVF.

For those women trying to get pregnant, knowing you have endometriosis and treating it is critical to your success in achieving a natural pregnancy. For women with pain symptoms, it currently takes 7-10 years to get properly diagnosed. That’s because physicians miss or dismiss your symptoms. Not anymore.

If endometriosis is suspected, it can be treated surgically through laparoscopy, managed through medication or other treatments and if trying to get pregnant, addressed through hormone suppression drugs for 60 days such as Depot Lupron. These drugs suppress the inflammation allowing the embryo to attach and grow on the uterine lining, If you have tried to get pregnant unsuccessfully, seeing a fertility doctor may be the best solution.

For more information. Visit us at MyReceptiva.