MyReceptivaTM Test Information

Learn more about the test, successful collection procedures and how to understand your results.

Talk To Your Healthcare Provider

To help you speak with your healthcare provider about MyReceptivaTM testing, please download this document and bring it with you on your next visit.

Prepare for your visit

Understanding Your Results

Identifying uterine lining inflammation is the most powerful tool available for the detection of endometriosis. Only laparoscopic surgery to diagnose endometriosis has been proven to be more effective.

Positive result

BCL6 Positive Result

If your BCL6 results are positive, you have a 90% or greater chance that endometriosis is present and confirmable via laparoscopy.*

A positive MyReceptivaTM result indicates the likelihood that endometriosis will be found via surgery. The positive result helps justify the need for further follow up with an endometriosis specialist. For women with fertility issues, various treatment options such as hormone suppression can also be considered to provide new pathways to pregnancy.

negative result

BCL6 Negative Result

If your BCL6 results are negative, you have less than 7% chance that endometriosis will be found via laparoscopy.

A negative MyReceptivaTM test result provides assurance that endometriosis is unlikely to be the cause of undiagnosed pain or the primary cause of fertility issues. However, results should be taken in context to your complete medical history.

Please note: The MyReceptivaTM test is a detection tool and should not be used for diagnostic confirmation. The test detects the presence of the BCL6 protein, a marker of inflammation proven to be highly associated with endometriosis. Providers are encouraged to refer patients for further evaluation to a qualified gynecologic surgeon specializing in endometriosis.

*References: 1. Endometrial BCL6 overexpression in Eutopic endometrium of women with endometriosis, Evans Hoeker et al., Reproductive Science Sep 2016 2. BCL-6 Overexpression as a Predictor for Endometriosis in Patients Undergoing In Vitro Fertilization. Journal of the society of laparoscopic and robotic surgeons,, C Nezhat, et al. Oct. 2020 3. Positive Predictive Value of Endometiral BCL6 overexpression in patients with Pathology confirmed endometriosis. Rambhatla et al., F&S Apr 2020

What Is Included When You Get Your Results

Your pathology report will provide you with a detailed analysis of your results. The report will include:

  • Diagnosis and interpretation of the MyReceptiva markers ordered.
  • Full pathology analysis of tissue, ruling out malignancy, atypical cells or any other
    concerning issues such as potential infections.
  • Signature of board certified pathologist that reviewed your case.
View a Sample Report

Find a Specialist

There are many specialists that can assist in your follow-up. Your regular doctor can make recommendations for local or regional endometriosis specialists. In addition, the following articles and resources are available through these trusted organizations and can further help you identify experts in your metro area or region of the US.

If you are a specialist who would like to be included in our directory, please click here to fill out our form.

Visit our Endometriosis Specialists page for a curated list of physicians available to perform MyReceptivaTM biopsies and provide treatment and counseling.

Endometriosis specialists

Biopsy Collection Information for Patients and Providers

The MyReceptivaTM test is based on a timed biopsy 7 to 10 days following the detection of ovulation. For your convenience, every MyReceptivaTM Test Kit order comes with a complimentary home use Ovulation Kit. Once ovulation is detected, your biopsy window opens up 7 to 10 days later. For example, if you detect ovulation with the kit on a Monday, your biopsy window opens the following Monday for 4 days.

Call your provider upon ovulation detection to schedule your biopsy. And don’t forget to bring your collection kit, as most provider offices do not routinely stock the MyReceptivaTM Kit in their office. For further assistance, please download and print these detailed instructions.

collection instructions

Publications

Learn more from studies showing the correlation of a positive BCL6 result to endometriosis or IVF failure.

  • BCL-6 Overexpression as a Predictor for Endometriosis in Patients Undergoing In Vitro Fertilization

    Camran Nezhat, MD, Anupama Rambhatla, MD, Catarina Miranda-Silva, MD, Atena Asiaii, MD, Kimsa Nguyen, BS, Aimee Eyvazzadeh, MD, Salli Tazuke, MD, Shruti Agarwal, DO, Sunny Jun, MD, Azadeh Nezhat, MD, Robert A. Roman, MD

    Summary: The Positive predictive value of the ReceptivaDx™ was 96% confirmed by surgical laparoscopy.

    Read More

  • Endometrial BCL6 testing for the prediction of in vitro fertilization outcomes.

    December 2017

    Laura D. Almquist, M.D., Creighton E. Likes, M.D., Benjamin Stone, B.S., Kaitlin R. Brown, B.S., Ricardo Savaris, M.D., Ph.D., David A. Forstein, D.O., Paul B. Miller, M.D., Bruce A. Lessey, M.D., Ph.D.

    Summary: Demonstrates the predictive value of positive BCL6 results without treatment with poor live birth success

    Read More

  • Medical or surgical treatment before embryo transfer improves outcomes in women with abnormal endometrial BCL6 expression.

    January 2019

    Creighton E. Likes, Leah J. Cooper, Jessica Efird, David A. Forstein, Paul B. Miller, Ricardo Savaris, Bruce A. Lessey

    Summary: Women with suspected endometriosis and high endometrial BCL6 expression have worse reproductive outcomes following embryo transfer, including a high miscarriage rate and low clinical pregnancy and live birth rates compared to cycles pre-treated with medical and surgical management.

    Read More

  • Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium

    April 2019

    Harvey J. Kliman, M.D., Ph.D.a and David Frankfurter, M.D.

    Summary: Highlights the importance of assessing the endometrium as the cause of unexplained implantation failure.

    Read More

  • Unexplained recurrent pregnancy loss and unexplained infertility: twins in disguise.

    October 2019

    Chelsea W Fox, Ricardo F Savaris, Jae-Wook Jeong, Tae Hoon Kim, Paul B Miller, Creighton E Likes, David P Schammel, Steven L Young, Bruce A Lessey

    Summary: Endometrial BCL6 expression is elevated to a similar degree in women with unexplained recurrent pregnancy loss and unexplained infertility compared to fertile controls likely due to endometriosis.

    Read More

  • Outcomes in women with IVF failure who tested positive for BCL6 using ReceptivaDx testing: Effect of treatment on subsequent embryo transfer

    April 2020

    Dan Angress

    Summary: Demonstrates the positive impact of treatment for positive BCL6 patients on live births success.

    Read More

  • Unexplained Euploid Embryo Transfer Failure: Testing and Treatment Options

    March 2024

    Bruce A Lessey MD, PhD1, Allan Dong MD1, David Wininger PhD1, Jeffrey L Deaton MD1, Ricardo Savaris MD, PhD2.

    Summary; Patients who had failed IVF more than once, had their embryos genetically tested and then treated for positive BCL6 had live birth rates comparable to first time transfers for women who had not failed. Positive BCL6 Women who chose not to be treated fared poorly in live birth rates.

    Read More

  • Endometrial BCL6 Overexpression in Eutopic endometrium of women with endometriosis.

    September 2016

    Evans-Hoeker E, Lessey BA, Jeong JW, Savaris RF, Palomino WA, Yuan L, Schammel DP, Young SL.

    Summary: First paper showing role of BCL6 as predictor of endometriosis using an endometrial biopsy.

    Read More

  • KRAS Activation and overexpression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance.

    July 2017

    Jung-Yoon Yoo1,2, Tae Hoon Kim1, Asgerally T. Fazleabas1,3, Wilder A. Palomino4, Soo Hyun Ahn 5, Chandrakant Tayade5, David P. Schammel6, Steven L. Young7, Jae-Wook Jeong1,3 & Bruce A. Lessey8.

    Summary: Endometriosis is an inflammatory condition that is associated with progesterone resistance and cell proliferation, resulting in pain, infertility and pregnancy loss. This study data suggest that KRAS, SIRT1 and BCL6 are coordinately over-expressed in eutopic endometrium of women with endometriosis and likely participate in the pathogenesis of endometriosis.

    Read More

  • BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis

    May 2022

    Frank Louwen, Nina-Naomi Kreis, Andreas Ritter, Alexandra Friemel, Christine Solbach, and Juping Yuan

    Summary

    Read More

Take charge of your health.

  • The facts are clear. Endometriosis is missed or overlooked by many physicians.
  • Almost half of women saw 3 to 5 providers before being diagnosed.
  • This is your body and your choice.

  • Asking for the test with a kit in your hands and the facts to support you ensures your doctor will listen to your concerns.

Order Your Collection Kit

Endometriosis affects an estimated 2 to 10% of American women between the ages of 25 and 40, which is why we’re determined to help provide answers and solutions. Millions of women have suffered from endometriosis and have been able to find solutions.

We are here to help.