How the BCL6 Protein Marker Is Used in Endometriosis Testing
Endometriosis is an often undiagnosed but common condition. It could lead to recurrent pregnancy loss or unexplained infertility due to inflammation in the uterine lining. Through a biopsy, the BCL6 protein marker can be used to detect this inflammation and endometriosis. Here is what you need to know about the BCL6 protein marker and endometriosis testing:
What Is the BCL6 Protein Marker?
B-cell lymphoma 6 (BCL6) is a protein associated with inflammation. Women with increased BCL6 levels within their endometrial tissue may have undiagnosed endometriosis. The inflammation caused by this condition may inhibit pregnancy and increase the risk of pregnancy loss. Other diagnostic methods of endometriosis generally rely on visible signs, but BCL6 testing tests for the molecular presence of inflammation.
How Does BCL6 Testing Differ From Other Methods?
Traditional diagnostic methods for endometriosis rely on imaging and laparoscopy. MRIs can help with identification, but they might miss milder cases. Laparoscopy, a surgical method, is another method to obtain an accurate diagnosis. The procedure is invasive and requires recovery time.
BCL6 tests can identify milder or silent cases of endometriosis by examining signs of inflammation at a molecular level. Testing for BCL6 is non-surgical and does not require any anesthesia or recovery. The biopsy required for the test is also done in the office, making it fast and more convenient than surgery.
How Is BCL6 Used in Endometriosis Testing?
BCL6 testing involves the analysis of an endometrial tissue sample collected by means of a biopsy. Providers then use the MyReceptiva™ test to detect elevated BCL6 levels in the sample. Increased levels of this protein marker indicate resulting endometrial inflammation, allowing for a more accurate diagnosis of endometriosis.
The MyReceptiva test allows for earlier detection compared to other traditional endometriosis testing methods. Earlier detection allows for the quick implementation of treatment plans and improves the likelihood of successful pregnancy.
Who Should Use BCL6 Testing?
The MyReceptiva test can be beneficial to women who are facing unexplained infertility, recurrent pregnancy loss, or failure to conceive. Another group of candidates includes women whose providers suspect they have endometriosis despite the absence of visible signs. Women who are looking to do IVF can also use BCL6 testing as a preemptive measure to test for inflammation before treatment.
What Happens if the Test Is Positive?
A positive test indicates the presence of endometrial inflammation, and a diagnosis of endometriosis is then given. Your provider will work with you to formulate a treatment plan that depends on factors like the condition’s severity and your pregnancy goals.
Anti-inflammatory medications might work for milder cases. Hormonal therapy and surgery are options for more severe cases. If you are planning to undergo IVF, implementing a thorough and effective treatment plan will increase the likelihood of a successful outcome.
Get Testing for Endometriosis Today
BCL6 testing is a diagnostic tool used to identify endometriosis and can help to provide women with answers regarding pregnancy loss and unexplained infertility. Early detection and management of endometrial inflammation is the first step in dealing with endometriosis. Contact MyReceptiva to learn more about our services.
