What To Expect and How an Endometriosis Test Works
Endometriosis affects about 10% of women of reproductive age worldwide, and it typically takes 7 to 10 years to receive a diagnosis on average. The MyReceptiva test helps identify endometriosis by detecting a protein marker in the uterine lining, offering a non-surgical alternative to diagnosis. Unlike traditional approaches that rely on laparoscopy, this method can improve diagnostic accuracy and provide earlier detection. Here’s what to expect and how endometriosis testing works:
The MyReceptiva Test
The MyReceptiva test detects levels of a protein called BCL6 in the uterine lining. Elevated BCL6 is associated with processes involved in endometriosis, including inflammation, immune response, and abnormal cell growth. When this marker is present at higher levels, it can serve as an indicator of uterine inflammation; it also provides key insights into factors linked to endometriosis.
The test was developed and patented by researchers with more than 25 peer-reviewed publications. It has been used to evaluate over 35,000 women through the BCL6 testing approach and is currently utilized by more than 450 fertility centers worldwide. MyReceptiva provides testing kits with expedited overnight shipping, along with access to pathology reports.
The Biopsy Collection
A timed endometrial biopsy is performed approximately 7 to 10 days after ovulation. Each collection kit includes a complimentary at-home ovulation test to help confirm the timing. Once ovulation is detected, the biopsy window opens and remains available for four days.
The biopsy procedure itself is completed during a standard office visit by a trained women’s healthcare provider. During the procedure, a small sample of endometrial tissue is collected and placed into a preservative vial to maintain specimen integrity. After collection, the provider sends the sample overnight to the laboratory for analysis.
Patients can bring a collection kit to the appointment, as some clinics do not keep the MyReceptiva™ Kit in stock. For the best results, scheduling should be arranged promptly once ovulation is confirmed. Such scheduling makes sure the appointment falls within the four-day collection window. Patients should also wait at least one full menstrual cycle before undergoing the biopsy; this helps verify that medications or hormonal contraceptives do not interfere with the accuracy of the results.
The Results
The pathology report includes a full tissue analysis to rule out malignancy, atypical cells, or potential infections. It offers an interpretation of BCL6 marker expression along with an official review and signature from a board-certified pathologist. A positive BCL6 result means there is a 90% or greater probability that endometriosis is present and confirmable through laparoscopic surgery.
This result supports referral to an endometriosis specialist and, for women with fertility issues, may open pathways to treatment options such as hormone suppression. A negative BCL6 result means there is less than a 7% chance that endometriosis will be found via laparoscopy; this indicates that endometriosis is unlikely to be the primary driver of undiagnosed pain or fertility problems. This allows other underlying factors to be explored.
The Test Candidates
Candidates for an endometriosis test include individuals experiencing unexplained pelvic or abdominal pain. Other issues include pain during or after intercourse or recurrent bladder or bowel discomfort. Those with a family history of endometriosis may also benefit from evaluation. For patients with fertility concerns, the test is often ideal for women under 35 who have been unable to conceive after 12 months of regular, unprotected intercourse. It is also appropriate for women who have experienced one or more consecutive first-trimester miscarriages; it is also ideal for those who are planning to pursue in vitro fertilization (IVF). Because endometriosis is a common underlying factor in female infertility, identifying it early helps inform more targeted treatment decisions. It also guides appropriate next steps in care.
Explore an Endometriosis Test
MyReceptiva test results should always be interpreted in the context of a patient’s full medical history. The test provides objective, biology-based information that may help speed up referrals and reduce the long delays often associated with diagnosing endometriosis. Contact us today to order a collection kit and take the next step toward understanding your results and endometriosis diagnosis.
